Genotype 1 most common variant of hepatitis C worldwide


Amsterdam, 29th July 2014 –

1217 studies
Genotype 1 is the world’s most common genotype of hepatitis C virus (HCV), according toresearchers from the United Kingdom. Their findings are published in the journal Hepatology. With more than 83 million infected patients, their study shows that genotype 1 is the most common variation of hepatitis universally. A third of these people live in East Asia. Genotype 3 is the most prevalent after type 1, with more than 54 million cases worldwide.

Genotypes 1 and 3

At 46 percent of all HCV cases, analysis shows that HCV genotype 1 is the most prevalent, followed by genotype 3 at 30 percent. Researchers highlight that genotypes 1 and 3 are most dominant regardless economic status. However, lower-income countries were found to have larger concentrations of genotypes 4 and 5.

Liver cirrhosis and death

According to the World Health Organization (WHO), HCV remains one of the most common diseases worldwide, with over 150 million cases worldwide. Previous research shows that chronic HCV leads to liver cirrhosis, hepatocellular carcinoma (HCC), or liver cancer, liver failure and death. The WHO reports that 350 thousand to half a million deaths each year are caused by liver diseases related to HCV.

New therapies
“While the risk of infection with HCV is decreasing in developed countries, the number of deaths from HCV will continue to increase over the next 20 years”, says co-author Dr. Jane Messina from the University of Oxford in the United Kingdom. 
Dr. Eleanor Barnes from the University of Oxford adds: “The testing of new therapeutics is still dependent upon the knowledge of the viral genotype. Non-genotype 1 HCV occurs in more than half of all HCV cases. Our study provides evidence of genotype prevalence for specific countries and regions that will help improve acces to new therapies to combat HCV.”

Source: Hepatology, medical news today